Studies of magnesium – hydroxyapatite micro/nano film for drug sustained release

Abstract

It is challenging to fabricate the bioactive films containing magnesium (Mg) particles to obtain a film with a porous structure. These microporous structures facilitate the diffusion of the drug covered by the Mg-HA film to achieve sustainable drug release. Herein, ciprofloxacin hydrochloride (CIP) film as the drug representative is obtained by low energy electron beam deposition (LEBD) to verify the sustained release effect of Mg-HA film. Therefore, the fourlayer composite films with a distribution of the CIP are obtained using the layered growth of CIP film and Mg-HA film by the PLD-LEBD coupling technology. The results showed that Mg-HA film not only prolonged the CIP release period, but also enhanced the drug release in the middle and late stages.