Цитотоксические и фотомодифицирующие свойства экстрактов из распространенных лишайников юго-востока Беларуси

Abstract

The photomodifying and cytotoxic profile obtained for thirty-five extracts isolated from five species of distributed lichens in the South-East of Belarus was analyzed. According to the research results, the extracts were classified as toxic and non-toxic to human keratinocytes (HACaT). The dependence of the quantitative toxicity indicators of extracts on the lichen species, to a lesser extent, on the extraction conditions was revealed. Extracts that reduce the toxic effect of ultraviolet radiation on skin cells and possess photosensitizing properties were revealed. A group of the extracts that revealed the properties of a radiation modifier was identified. The statistical analysis of the factors associated with the modification of the radiation effects by extracts showed the greatest influence on this indicator of the solvents used for extraction. Most of the extracts show both the photoprotective and photosensitizing effects in the extract concentration range from 2.5 to 5 μg/ml. Increasing the concentration to 10 μg/ml, on average, enhances their photosensitizing properties. The statistical analysis confirmed the significant concentration-dependent changes in the photomodifying properties of a number of extracts.