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Title: Studies of magnesium – hydroxyapatite micro/nano film for drug sustained release
Authors: Jinxing, Gao
Xiaohong, Jiang
Rogachev, A.V.
Рогачёв, А.В.
Issue Date: 2021
Publisher: F. Skorina Gomel State University
Citation: Jinxing, G. Studies of magnesium – hydroxyapatite micro/nano film for drug sustained release / Gao Jinxing, Jiang Xiaohong, A.V. Rogachev // Inter-Academia 2021 : the 19th International Conference on Global Research and Education (Gomel, Belarus, 20 – 22 October, 2021) / S.A. Khakhomov, I.V. Semchenko, O.M. Demidenko, D.L. Kovalenko, A.A. Sereda, T.V. Lozovskaya ; F. Skorina Gomel State UniversityGomel. - Gomel, 2021 - P. 141-143.
Abstract: It is challenging to fabricate the bioactive films containing magnesium (Mg) particles to obtain a film with a porous structure. These microporous structures facilitate the diffusion of the drug covered by the Mg-HA film to achieve sustainable drug release. Herein, ciprofloxacin hydrochloride (CIP) film as the drug representative is obtained by low energy electron beam deposition (LEBD) to verify the sustained release effect of Mg-HA film. Therefore, the fourlayer composite films with a distribution of the CIP are obtained using the layered growth of CIP film and Mg-HA film by the PLD-LEBD coupling technology. The results showed that Mg-HA film not only prolonged the CIP release period, but also enhanced the drug release in the middle and late stages.
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